The Middle East remains on high alert after Iran launched waves of missiles and drones at Israel and US-linked sites across the region, following the killing of Ayatollah Ali Khamenei in a joint US-Israeli strike. Here is the latest:

Iran has fired more than 25 waves of missiles and drones at targets in Israel, Bahrain, Qatar, the UAE, Kuwait and Iraq, according to Western officials. Several civilian areas have been hit, and both sides report casualties.

Israel says it has struck sites “in the heart of Tehran”, with large explosions seen across the capital. Iranian state media says Tehran has suffered more than 60 attacks in 24 hours.

Heavy damage has been reported in parts of Israel. A missile strike in Beit Shemesh killed at least four people and injured about 20 others. There are also unconfirmed reports of a collapsed structure near Jerusalem.

Across the Gulf, Dubai and Abu Dhabi have faced repeated explosions. Dubai Airport has suspended all flights, and staff have been injured by falling debris. Widespread cancellations continue across the region.

British forces have shot down Iranian drones threatening UK bases, and the Foreign Office is advising against all but essential travel to several Gulf states. UK nationals are being told to shelter in place.

Russia has condemned the US-Israel strike that killed Khamenei, warning of the risk of a wider catastrophe. President Vladimir Putin has sent a formal letter of condolence to Iran.

Air-raid sirens continue to sound across Israel as interceptions take place. In Bahrain, Qatar and Kuwait, authorities report regular missile activity and have warned residents to stay indoors.